9/15/2023 0 Comments Taurine and creatineThalamus histopathological analysis and MRI anatomic images of thalamus and brain in LALF mice. Ace indicates acetate Alc, alcohol Cho, choline-containing compounds Cr, creatine GABA, γ−aminobutyric acid Glc, glucose Gln, glutamine Glu, glutamate Glx, glutamate + glutamine GSH, glutathione Ins, myo-inositol Lac, lactate MM, macromolecules NAA, N-acetylaspartate NAAG, N-acetylaspartylglutamate PCr, phosphocreatine Tau, taurine tCr (total creatine), Cr + PCr. Data presented as mean ± standard error of the mean. The NAA peak heights were used to normalize the MR spectra as there was no statistical difference in the NAA peak heights between the groups in the measured regions. Comparisons of the neurochemical concentrations between control- (n = 7) and alcohol-treated (n = 7) mice in hippocampus (E) and thalamus (F). (A) Hippocampus from an age-matched control mouse, (B) hippocampus from a 7-month-old Lieber-DeCarli alcohol liquid diet treated mouse, (C) thalamus from an age-matched control mouse, and (D) thalamus from a 7-month-old Lieber-DeCarli alcohol liquid diet–treated mouse. Representative in vivo 1H-MR spectra and corresponding voxel locations. Magnetic resonance spectroscopy represents a sensitive and noninvasive measurement of pathological alterations in the brain, which may provide insight into the pathogenesis underlying the development of MHE.Īlcohol-induced minimal hepatic encephalopathy alcoholic liver fibrosis creatine magnetic resonance spectroscopy taurine thalamus. Chronic long-term alcohol consumption gives rise to advanced liver fibrosis, neurochemical changes in the nuclei, and behavioral changes which may be linked to NDF. Thalamic levels of taurine and creatine were significantly diminished and strongly correlated with alcohol-induced behavioral changes. Glutamine levels were higher in both the thalamus and hippocampus of alcohol-treated mice than in controls. Proton magnetic resonance spectroscopy of the brain and behavioral testing were performed to determine neurochemical alterations and their relationships to behavioral changes in LALF. To gain insight into the development of alcoholic liver disease-induced neurological dysfunction (NDF), a mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes in neurochemical levels in the thalamus and hippocampus that relate to behavioral changes. Clinical management may be delayed due to the lack of in vivo quantitative methods needed to reveal changes in brain neurobiochemical biomarkers. Minimal hepatic encephalopathy is defined as hepatic encephalopathy with cognitive deficits and no grossly evident neurologic abnormalities. Minimal hepatic encephalopathy (MHE) is highly prevalent, observed in up to 80% of patients with liver dysfunction.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |